VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Structural and functional characteristics of the sarcoplasmic reticulum membranes of the skeletal muscles in thyrotoxicosis

   
Tashmukhamedov B.A., Zamaraeva M.V., Gagel'gans A.I., Kliuev S.N., Salakhutdinov B.A.
PubMed Id: 6278759
Year: 1981  Volume: 27  Issue: 6  Pages: 769-773
A rate of CA2+ accumulation and efficiency of Ca2+-pump were decreased in the fractions of skeletal muscle sarcoplasmic reticulum isolated from rabbits with thyrotoxicosis. Temperature of phase transition in membranes of sarcoplasmic reticulum was changed by 4-5 degrees towards low temperatures. Under conditions of thyrotoxicosis fatty acid composition of total lipids from the sarcoplasmic reticulum fractions was altered as follows: amount of palmitic acid was increased 1.4-fold but oleic and arachidonic acids were decreased 21.8% and 40.5%, respectively. Modification of Ca2+-transport properties in sarcoplasmic reticulum caused by long-term administration of thyroid hormones into animals appears to alter the membrane protein-lipid composition.
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Tashmukhamedov, B. A., Zamaraeva, M. V., Gagel'gans, A. I., Kliuev, S. N., Salakhutdinov, B. A. (1981). Structural and functional characteristics of the sarcoplasmic reticulum membranes of the skeletal muscles in thyrotoxicosis. Voprosy meditsinskoi khimii, 27(6), 769-773.
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