VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Genetic differences in the excretion of phenazepam-14C

   
Seredenin S.B., Zin'kovskii V.G., Golovenko N.Ia., Rybina I.V.
PubMed Id: 6121421
Year: 1981  Volume: 27  Issue: 6  Pages: 788-790
Content of 14C-phenazepame and its metabolites was studied in feces and urine of mice strains C57BL/6 and BALB/ c after intraperitoneal administration of the preparation at a dose of 14 mg/kg. Concentration of phenazepame and of its trihydroderivative was higher in urine of the BALB/c strain mice than in C57BL/6 strain that corresponded to genetic differences of the tranquilizer metabolism in the animal strains studied.
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Seredenin S.B., Zin'kovskii V.G., Golovenko N.Ia., Rybina I.V. (1981) Voprosy meditsinskoi khimii, 27(6), 788-790.
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