VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Kinetics of the organ and tissue distribution of D-alpha-(5 methyl-3H)-tocopherol as a function of the age of animals

   
Spryshkova R.A., Spryshkova N.A., Serebriakov N.G., Spirichev V.B., Zubenkova E.S.
PubMed Id: 7336660
Year: 1981  Volume: 27  Issue: 6  Pages: 835-840
Principles of an intertissue distribution of D-alpha(5 methyl-3H)tocopherol were studied depending on ontogenesis of animals. The tissues were divided into three groups via kinetics of the label distribution: tissues responsible for transport and recirculation of the vitamin, tissues-consumers from which the third group was derived--endocrine glands with the maximal rate of the label incorporation within a week. In preadolescent rats the rate of the vitamin consumption was high due to increase in hepato-intestinal recirculation and to optimal conditions of tocopherol intestinal absorption. In ageing rats the rate of the vitamin utilization was decreased as a result of lowering of its absorption in intestine but the vitamin E metabolism was increased in the tissue-consumers considering that the label content was decreased in tissues, the intestinal phase was prolonged two-fold and more as compared with young animals and that excretion of the vitamin metabolites with urine was increased. High level of radioactivity in feces appears to occur because of presence of tocopherol nonabsorbed in intestine.
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Spryshkova, R. A., Spryshkova, N. A., Serebriakov, N. G., Spirichev, V. B., Zubenkova, E. S. (1981). Kinetics of the organ and tissue distribution of D-alpha-(5 methyl-3H)-tocopherol as a function of the age of animals. Voprosy Meditsinskoi Khimii, 27(6), 835-840.
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