VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Features of the regulation of key enzymes involved in glycolysis and the pentosephosphate shunt in tissues with different functional specializations

   
Panin L.E., Tret'iakova T.A., Russkikh G.S., Voitsekhovskaia E.E.
PubMed Id: 6281988
Year: 1982  Volume: 28  Issue: 2  Pages: 26-30
Under conditions of acute and chronic stress carbohydrate metabolism was decreased in muscles and liver tissue, increased in adrenal glands and unaltered in brain. cAMP at concentration 10(-5)M decreased the rate of glycolysis in liver tissue and increased it slightly in adrenal glands. The inhibitory effect of cAMP was not decreased by 2',3'-AMP and was reversed completely by the protein inhibitor of proteinkinase. cAMP inhibited hexokinase (HK) isoenzymes 2 and 3 as well as glucose-6-phosphate dehydrogenase (G6PD) isoenzymes 1 and 2, activities of HK 1 and G6PD 3 and 4 were unaltered. The decrease in activities of HK and G6PD appears to be related to phosphorylation of proteinkinase; lack of the effect of cAMP in adrenal glands was apparently due to absence of corresponding cAMP-dependent proteinkinase in this tissue.
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Panin, L. E., Tret'iakova, T. A., Russkikh, G. S., Voitsekhovskaia, E. E. (1982). Features of the regulation of key enzymes involved in glycolysis and the pentosephosphate shunt in tissues with different functional specializations. Voprosy Meditsinskoi Khimii, 28(2), 26-30.
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