VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Molecular heterogeneity and complex-forming capacity of plasma ribonucleases in leukemia

   
Shliakhovenko V.A., Negrei G.Z., Glinskii G.V., Ivanova A.B., Zyl' N.I.
PubMed Id: 7080479
Year: 1982  Volume: 28  Issue: 2  Pages: 58-63
Molecular polymorphism and complex-formation ability of ribonucleases, obtained from blood plasma of healthy persons and of patients with acute leukemia as well as from blood plasma of rats with experimental Svec leukemia, were studied using isoelectric focusing, ion exchange chromatography, gel and membrane filtration techniques. Molecular forms of the enzyme were not altered in leukemic patients and animals as compared with normal state but the ability of the enzyme to form complexes with other blood plasma components was markedly decreased in the pathology. Increase in content of polyamines, found in blood of leukemic patients and animals, might be among the reasons responsible for decrease of the enzyme ability to bind with blood plasma proteins.
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Shliakhovenko V.A., Negrei G.Z., Glinskii G.V., Ivanova A.B., Zyl' N.I. (1982) Voprosy meditsinskoi khimii, 28(2), 58-63.
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