VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of temporary occlusion of coronary artery on oxidation of fatty acids in heart mitochondria

   
Toleĭkis A.I., Bartkene V.S., Prashkiavichius A.K.
PubMed Id: 7101820
Year: 1982  Volume: 28  Issue: 3  Pages: 83-88
The oxidation rates of acetate, acetyl carnitine, caprinate, palmitoyl carnitine and palmitoyl CoA were studied in mitochondria of rabbit heart after short-term (60 min) occlusion of coronary artery with subsequent reperfusion within 1 day and 6 days. Oxidation of these substances was similarly decreased. Incomplete oxidation of palmitoyl carnitine was characteristic for mitochondria impaired with ischemia. The data obtained suggest that the outer carnitine palmitoyl transferase was the limiting enzyme for the palmitoyl CoA oxidation in control and impaired mitochondria. The rate of palmitoyl carnitine and caprinate oxidation was apparently decreased at the initial steps of oxidation as soon as consumption of acetate in the tricarboxylic acid cycle exceeded distinctly its formation from these substances.
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Toleĭkis A.I., Bartkene V.S., Prashkiavichius A.K. (1982) Voprosy meditsinskoi khimii, 28(3), 83-88.
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