VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Specificity characteristics of estrogen interaction with the cytoplasmic receptors of the uterus and oviducts in green monkeys (Cercopithecus griseus)

   
Fanchenko N.D., Alekseeva M.L., Sturchak S.V., Novikov E.A.
PubMed Id: 7113055
Year: 1982  Volume: 28  Issue: 4  Pages: 56-58
The specificity of interaction in Cercopithecus griseus uterus and oviduct cytosol receptor systems with 14 estrogenic substances has been characterized. It was shown that the activity of steroid-receptor interaction was mainly due to presence of hydroxyl groups in C3- and C17b-positions. The nearest environment of these functional groups in molecules affected also the affinity of steroids to the systems investigated. Analysis of the cytosol estrogen-receptor system specificity from Cercopithecus griseus, guinea pig, human uterus and oviduct showed the general pattern of the estrogen binding to the above-mentioned systems. Similarity was also noted between these Cercopithecus griseus and human estrogen-receptor systems.
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Fanchenko, N. D., Alekseeva, M. L., Sturchak, S. V., Novikov, E. A. (1982). Specificity characteristics of estrogen interaction with the cytoplasmic receptors of the uterus and oviducts in green monkeys (Cercopithecus griseus). Voprosy Meditsinskoi Khimii, 28(4), 56-58.
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