VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Enzyme characteristics of the rat liver in ontogeny in chronic alcohol intoxication

   
Tutel'ian V.A., Sorokovaia G.K., Savvina L.V., Avrent'eva L.I., Vasil'ev A.V.
PubMed Id: 7202288
Year: 1982  Volume: 28  Issue: 4  Pages: 96-101
Chronic alcohol intoxication led to an increase in activity of alcohol dehydrogenase and to decrease -- of aldehyde dehydrogenase and the microsomal ethanol oxidizing system (MEOS) with simultaneous activation of cytochrome P-450 in liver tissue of rats during ontogenesis. Ethanol, which did not affect the enzymatic status of lysosomes within ontogenesis (alpha- and beta-glucosidases, alpha- and beta-galactosidases, alpha-mannosidase, beta-N-acetylglucosaminidase, beta-xylosidase, beta-glucuronidase, beta-N-acetyl galactosaminidase acid RNAase, arylsulfatases A and B, cathepsin D), activated the majority of hydrolases in both embryonal and postnatal periods of development. Distinct increase in lipoperoxidation was detected under conditions of chronic alcohol intoxication.
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Tutel'ian V.A., Sorokovaia G.K., Savvina L.V., Avrent'eva L.I., Vasil'ev A.V. (1982) Voprosy meditsinskoi khimii, 28(4), 96-101.
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