VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Parameters of interaction of nitrophenols with different chemical structure with albumin, and their toxicity

   
Luik A.I., Luk'ianchuk V.D.
PubMed Id: 7179833
Year: 1982  Volume: 28  Issue: 5  Pages: 48-51
Chemical structure of a series of nitrophenols and their derivatives was studied in relation to their toxicity and complex-formation ability (association constant, amount of binding sites) with human blood serum albumin. Five compounds were studied using equilibrium dialysis and spectrofluorimetry. The nitrophenols, containing a hydrocarbon radical, exhibited distinctly higher affinity to albumin; substitution of one or two nitrogroups by aminogroups led to complete loss of the affinity to the protein. Dependence of acute toxicity on association constants of the complexes is discussed.
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Luik, A. I., Luk'ianchuk, V. D. (1982). Parameters of interaction of nitrophenols with different chemical structure with albumin, and their toxicity. Voprosy meditsinskoi khimii, 28(5), 48-51.
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