VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Phospholipid-phospholipid relations and changes of free radical lipid oxidation in biological membranes during alloxan diabetes

   
Karagezian K.G., Ovsepian L.M., Adonts K.G., Mamadzhanian L.Z., Petrosian A.M.
PubMed Id: 7179834
Year: 1982  Volume: 28  Issue: 5  Pages: 56-60
Quantitative and qualitative composition of phospholipids as well as lipid peroxidation were studied in outer and inner mitochondrial membranes and microsomal fraction from rat liver tissue under conditions of alloxane diabetes. In the diabetes amount of phospholipids, mainly cardiolipins and phosphatidylethanolamines, was increased in the inner and decreased in the outer mitochondrial membranes. Phosphatidylcholines and phosphatidylserines were increased in microsomal fraction. At the same time, lipid peroxidation was activated both in ascorbate- and NADPH-dependent systems of oxidation. These data suggest that lipid peroxidation affects the composition of mitochondrial membranes either by means of removing of the substances from membranes or via their redistribution between the subcellular fractions.
Download PDF:
Citation:

Karagezian, K. G., Ovsepian, L. M., Adonts, K. G., Mamadzhanian, L. Z., Petrosian, A. M. (1982). Phospholipid-phospholipid relations and changes of free radical lipid oxidation in biological membranes during alloxan diabetes. Voprosy meditsinskoi khimii, 28(5), 56-60.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)