VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of bicarbonate and insulin on energy metabolism in the mitochondria of rat liver

   
Kosenko E.A., Kaminskiĭ I.G., Derkachev E.F., Shchipakin V.N., Kondrashova M.N.
PubMed Id: 6760541
Year: 1982  Volume: 28  Issue: 6  Pages: 87-90
Administration of physiologically low doses of bicarbonate into rats caused an inhibition of oxidative phosphorylation and a transitory decrease in ATP content in liver mitochondria; at the same time, concentrations of malate and glutamate were unaltered and those of pyruvate and phosphoenolpyruvate were decreased. Insulin removed the bicarbonate effect on mitochondrial functions but affected only slightly the distribution of metabolites. Bicarbonate appears to activate pyruvate carboxylase and to inhibit succinate dehydrogenase as well as the operation of tricarboxylic acid cycle due to accumulation of oxaloacetate. The effect of insulin mimics acceleration of decarboxylation reactions in mitochondria.
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Kosenko, E. A., Kaminskiĭ, I. G., Derkachev, E. F., Shchipakin, V. N., Kondrashova, M. N. (1982). Effect of bicarbonate and insulin on energy metabolism in the mitochondria of rat liver. Voprosy Meditsinskoi Khimii, 28(6), 87-90.
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