VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Lipoproteins, apolipoproteins and blood plasma lipids in senility and longevity in men and women from Georgia and Kirghizia

   
Triufanov V.F., Denisenko A.D., Oleĭnik I.A., Lozovskiĭ V.T.
PubMed Id: 6836957
Year: 1983  Volume: 29  Issue: 1  Pages: 37-42
In men with increase of age from senile to longevity content of total cholesterol was practically unaltered (182 and 184 mg/100 ml), concentration of cholesterol in LPHD was increased from 52 mg up to 58.3 mg/100 ml simultaneously with unaltered content of LPLD cholesterol (102 mg/100 ml) and of LPVLD cholesterol (27.1 and 27 mg/100 ml). Triglycerides decreased from 136 mg down to 101 mg/100 ml. In women content of total blood cholesterol was about 218 mg/100 ml in senile age and 204 mg/100 ml in longevity and concentration of LPHD cholesterol--61 mg and 64.6 mg/100 ml, respectively. Contrary to men, in women a distinct decrease in content of LPLD cholesterol (from 127 mg to 110 mg/100 ml) as well as of triglycerides (from 154 to 145 mg/100 ml) were found on transition from senile age to longevity. Concentration of the apolipoproteins studied was unaltered in men on transition from senile age to longevity and in women concentration of apolipoprotein A-I decreased from 143 mg to 130 mg/100 ml and of apo-E from 11.1 mg to 9.2 mg/100 ml. The decrease in LPLD cholesterol content and increase of LPHD cholesterol, simultaneously with relatively low content of total blood cholesterol, appear to be considered among the reasons responsible for longevity and lesser risk of heart ischemic disease.
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Triufanov, V. F., Denisenko, A. D., Oleĭnik, I. A., Lozovskiĭ, V. T. (1983). Lipoproteins, apolipoproteins and blood plasma lipids in senility and longevity in men and women from Georgia and Kirghizia. Voprosy Meditsinskoi Khimii, 29(1), 37-42.
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