VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Function of liver mitochondria in alloxan diabetes

   
Agzamov K.H., Almatov K.T., Rakhimov M.M., Turakulov I.Kh.
PubMed Id: 6301156
Year: 1983  Volume: 29  Issue: 1  Pages: 61-66
State of liver mitochondria from rats with alloxane diabetes and the organelles polyenzyme systems were studied in correlation with glucose content in blood. At the initial and middle steps of the diabetes liver mitochondria were able to synthetize ATP but the rate of substrates oxidation was decreased. In severe forms of the diabetes latent impairments were developed in mitochondrial membranes. The phenomenon was accompanied by a decrease in activity of NADH-, succinate- and cytochrome c oxidizing systems as well as by a distinct decrease in the rate of ATP synthesis. Incorporation of exogenous cytochrome c into mitochondrial membranes was impaired and the mitochondria became more susceptible to the effect of heating and of hydrolytic enzymes degrading the organelles.
Download PDF:
Reference:

Agzamov K.H., Almatov K.T., Rakhimov M.M., Turakulov I.Kh. (1983) Voprosy meditsinskoi khimii, 29(1), 61-66.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
        

© Institute of Biomedical Chemistry, Moscow, Russia