VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Oxidation of phenazepam in isolated hepatocytes from white rats

   
Golovenko N.Ya., Meteshkin I.V., Kuznetsova S.V.
PubMed Id: 6136125
Year: 1983  Volume: 29  Issue: 3  Pages: 49-53
In isolated rat hepatocytes aromatic hydroxylation and oxidation of the 14C-phenazepame heterocycle were studied. Both these reactions proceeded with the linear rate in intact hepatocytes and aromatic hydroxylation predominated. After induction of cytochrome P-450 by phenobarbital the rate of the heterocycle oxidation was increased 3.6-fold. Rates of aromatic hydroxylation and the phenazepame heterocycle oxidation did not depend on administration of phenobarbital and 3-methyl cholanthrene into the animals. Effects of the factors studied (concentration of phenazepame, induction of cytochrome P-450 by means of phenobarbital and 3-methyl cholanthrene) on alterations in the rate of oxidation of both aromatic nuclei and the phenazepame heterocycle were estimated using dispersion analysis.
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Golovenko N.Ya., Meteshkin I.V., Kuznetsova S.V. (1983) Voprosy meditsinskoi khimii, 29(3), 49-53.
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