VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Acceleration of the excretion of monomeric 239Pu-citrate from the body as effected by pentacyne encapsulated in liposomes

   
Il'in L.A., Smirnov A.A., Ivannikov A.T., Parfenova I.M.
PubMed Id: 6353751
Year: 1983  Volume: 29  Issue: 4  Pages: 109-112
Liposomes, obtained by a modified procedure involving reverse phases, contained 2-3-times more 14C-pentacyne than the multilayer Banchem;s liposomes. Efficiency of pentacyne encapsulated in liposomes was higher, as compared with a non-encapsulated preparation in studies of urinary excretion of monomeric 239Pu-citrate in rats. Liposomal pentacyne increased most effectively the rate of the radionuclide excretion from liver tissue and skeleton as compared with the action of non-encapsulated complex-forming agent; as a result of which the radionuclide was excreted from liver tissue at a 1.6-2-times and from skeleton--with the 1.4-times higher rates. The both preparations increased the 239Pu excretion with urine and feces. The liposomal pentacyne accelerated an additional excretion of the nuclide with urine.
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Il'in, L. A., Smirnov, A. A., Ivannikov, A. T., Parfenova, I. M. (1983). Acceleration of the excretion of monomeric 239Pu-citrate from the body as effected by pentacyne encapsulated in liposomes. Voprosy Meditsinskoi Khimii, 29(4), 109-112.
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