VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Transketolase activity and thiamine diphosphate content in oncological patients

   
Trebukhina R.V., Tumanov V.N., Avdeĭchik L.A., Bobko I.N., Tsabenko I.I.
PubMed Id: 6649520
Year: 1983  Volume: 29  Issue: 5  Pages: 100-103
In blood of patients with cancer of stomach and mammary gland total thiamin content was measured by means of fluorimetric procedure, thiamindiphosphate (TDP)--by an enzymatic method, activity of transketolase was estimated in presence or in absence of TDP. Concentration of total thiamin in blood of healthy persons was 7.65 +/- 0.40 micrograms/100 ml; thiamindiphosphate--5.06 micrograms/100 ml activity of transketolase was 11.59 +/- 0.23 mmol/l. The "TDP" -effect was altered from 4% to 12%. In blood of oncological patients the concentration of total thiamin was 4.47 +/- 0.35 micrograms/100 ml and that of thiamindiphosphate 3.09 +/- 0.27 micrograms/100 ml, i.e. they were decreased by 40%. The transketolase activity was decreased by 20% (9.40 +/- 0.37 mmol/l); the "TDP" -effect was altered from 5% to 42%.
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Trebukhina, R. V., Tumanov, V. N., Avdeĭchik, L. A., Bobko, I. N., Tsabenko, I. I. (1983). Transketolase activity and thiamine diphosphate content in oncological patients. Voprosy Meditsinskoi Khimii, 29(5), 100-103.
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