Peroxidation of lipids in mitochondrial membranes, induced by enzymatic deamination of biogenic amines

Kagan V.E., Smirnov A.V., Savov V.M., Gorkin V.Z.
PubMed Id: 6710929
Year: 1984  Volume: 30  Issue: 1  Pages: 112-118
In presence of ferrous cations and ascorbate lipid peroxidation in mitochondrial membranes has been induced by incubation of fragments of the membrane devoid of catalase activity with amines which are substrates of monoamine oxidases of the B type (2-phenyl ethylamine, benzylamine) or transformed monoamine oxidases of type A (cadaverine). In the samples containing both cadaverine and benzylamine the highest stimulation of lipid peroxidation was noted. To the contrary, a substrate of the monoamine oxidases of the type A (serotonin) caused under the same conditions an antioxidative effect. The following conditions are obligatory to induce lipid peroxidation in mitochondria by incubation with amines: I. absence of catalase activity in the biomembranes; 2. presence of physiological concentrations of Fe2+. Physiological concentrations of ascorbate or alterations of pH in the samples caused additional stimulation of the lipid peroxidation.
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Kagan V.E., Smirnov A.V., Savov V.M., Gorkin V.Z. (1984) Voprosy meditsinskoi khimii, 30(1), 112-118.
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