VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Prevention of functional impairments of cardiac muscle mitochondria in emotional-painful stress

   
Meerson F.Z., Lifant'ev V.I., Malyshev V.V.
PubMed Id: 6324483
Year: 1984  Volume: 30  Issue: 1  Pages: 119-121
In experiments with 216 male rats emotional-painful stress impaired distinctly the oxidative phosphorylation and Ca2+ transport in heart muscle mitochondria. When gamma-hydroxybutyric acid, inderal, antioxidants ionol and isoptin were used as selective inhibitors of definite steps in the pathogenetic chain of stress heart impairments, these impairments of the mitochondrial functions were effectively prevented at the step of regulatory mechanisms responsible for the stress reactions.
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Meerson, F. Z., Lifant'ev, V. I., Malyshev, V. V. (1984). Prevention of functional impairments of cardiac muscle mitochondria in emotional-painful stress. Voprosy Meditsinskoi Khimii, 30(1), 119-121.
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