VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Indicators of phospholipase activity, lipid peroxidation and antioxidants in bronchial secretions from children with bronchopulmonary diseases

   
Krylov V.I., Olekhnovich V.M., Sorozin V.P., Zhogin S.V.
PubMed Id: 6710938
Year: 1984  Volume: 30  Issue: 1  Pages: 52-55
Lipid peroxidation, activity of phospholipases and antioxidants were studied in bronchial secretion products of 5-14 years old children with bronchial asthma. During the acute period of the disease of lipid peroxidation as shown by estimation of hydroperoxides, malone dialdehyde, diene conjugates and Shiff bases and the activity of endogenous phospholipases were distinctly stimulated. Simultaneously, deficiency of endogenous antioxidants, especially of beta-carotin, was observed in the bronchopulmonary system. Content of peroxides and the activity of phospholipases tended to decrease in bronchial secretion products during the periods of remission. The alterations found correlated with the severity of the disease. Role of lipid peroxidation in development of bronchial asthma is discussed.
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Krylov, V. I., Olekhnovich, V. M., Sorozin, V. P., Zhogin, S. V. (1984). Indicators of phospholipase activity, lipid peroxidation and antioxidants in bronchial secretions from children with bronchopulmonary diseases. Voprosy Meditsinskoi Khimii, 30(1), 52-55.
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