VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Glycosphingolipid content and beta-galacto- and beta-glucosidase activity of the blood in acute myocardial infarction and postinfarction cardiosclerosis

   
Sarkisova G.M., Sotskiĭ O.P., Episkoposian N.G., Sekoian E.S.
PubMed Id: 6429948
Year: 1984  Volume: 30  Issue: 2  Pages: 41-44
Content of acid and neutral glycosphingolipids was distinctly higher in blood plasma and cells of patients with acute myocardium infarction as compared with healthy persons. In leukocytes of the patients activity of beta-galactosidase, exhibiting pH optimum at pH 3.6, was decreased with simultaneous activation of beta-galactosidase at pH 5.5 and of beta-glucosidase (at pH 4.0 and 5.5). Content of glycosphingolipids in blood decreased in post-infractional myocardial cardiosclerosis but remained sufficiently high as compared with controls. In the cardiosclerosis activity of beta-galactosidase was increased at pH 3.6 as compared with the acute infarction; this activity was decreased at pH 5.5 Activity of beta-glucosidase at the both pH values (pH 4.0 and 5.5) was decreased down to the normal values.
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Sarkisova, G. M., Sotskiĭ, O. P., Episkoposian, N. G., Sekoian, E. S. (1984). Glycosphingolipid content and beta-galacto- and beta-glucosidase activity of the blood in acute myocardial infarction and postinfarction cardiosclerosis. Voprosy Meditsinskoi Khimii, 30(2), 41-44.
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