VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of adrenalectomy and anti-adrenergic preparations on the development of hyperenzymic and biochemical changes in the blood in burns

   
Petrov V.N., Khlopovskaia E.I., Dubovik B.V., Britun A.I.
PubMed Id: 6209853
Year: 1984  Volume: 30  Issue: 4  Pages: 64-67
Activities of alpha-hydroxybutyrate- and lactate dehydrogenases (HBDH, LDH), aspartate- and alanine aminotransferases (AST, ALT), alkaline phosphatase, alpha-amylase as well as content of total proteins, glucose, cholesterol, triglycerides and Ca2+ were estimated sprectrophotometrically in blood serum of rat males within 2 hrs after thermic burns of the III degree involving 15% the body surface. The burns caused about 2-fold increase in activities of LDH, HBDH and AST and in content of triglycerides in blood serum but did not affect the other biochemical patterns. Adrenalectomy, carried out within 3 days before the burns, accelerated and pseudoadrenalectomy decreased the early postburn enzymatic activation. Preadministration of reserpine, phentolamine and obsidane (propranolol) decreased distinctly the hyperenzymic reaction observed after the burn stress.
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Petrov, V. N., Khlopovskaia, E. I., Dubovik, B. V., Britun, A. I. (1984). Effect of adrenalectomy and anti-adrenergic preparations on the development of hyperenzymic and biochemical changes in the blood in burns. Voprosy Meditsinskoi Khimii, 30(4), 64-67.
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