VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Interaction of methylmethacrylate and acrylamide with the microsomal oxidation system of the rat liver

   
Kotlovskiĭ I.V., Grishanova A.Yu., Ivanov V.V.
PubMed Id: 6442037
Year: 1984  Volume: 30  Issue: 5  Pages: 44-47
A complex, exhibiting the maximal absorption at 385-388 nm and minimal at 414-420 nm, was formed after interaction between cytochrome P-450 and methylmethacrylate and acrylamide at 5 mM concentration. Acrylamide at concentrations higher than 6 mM induced the formation of modified type 11 differential spectra with maxima at 418 nm and minima at 385 nm. Methylmethacrylate and acrylamide stimulated utilization of NADPH and inhibited hydroxylation of 3,4-benzpyrene. Methylmethacrylate inhibited also N-demethylation of aminopyrine. After treatment of rats with the monomers activities of cytochromes P-450, b5 and NADPH-cytochrome c reductase were unaltered. Methylmethacrylate and acrylamide appear to interact with the microsomal oxidative system.
Download PDF:  
Citation:

Kotlovskiĭ, I. V., Grishanova, A. Yu., Ivanov, V. V. (1984). Interaction of methylmethacrylate and acrylamide with the microsomal oxidation system of the rat liver. Voprosy Meditsinskoi Khimii, 30(5), 44-47.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►