VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of isatin and its derivatives on some indicators of carbohydrate metabolism

   
Garalene V.N., Mazhilis L.I.
PubMed Id: 6528521
Year: 1984  Volume: 30  Issue: 5  Pages: 56-59
Effect of isatin and of three its derivatives on content of lactate, pyruvate and glycogen was studied in rat tissues. The substances studied, except of 5-butylisatin, decreased the content of lactic acid with simultaneous increase of glycogen content in liver tissue under normal conditions. The pyruvate content was most markedly altered in presence of 5-bromoisatin and 5-butylisatin. In deficiency of oxygen a distinct increase in content of lactate and pyruvate was noted in animal tissues after the 5-bromoisatin preadministration. Under conditions of oxygen deficiency the substances studied were of distinct significance for more economical utilization of glycogen in liver tissue and skeletal muscles.
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Garalene V.N., Mazhilis L.I. (1984) Voprosy meditsinskoi khimii, 30(5), 56-59.
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