VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Possible heterogeneity of cytoplasmic estrogen receptors

   
Alekseeva M.L., Minina L.S., Novikov E.A., Shchedrina R.N., Fanchenko N.D.
PubMed Id: 6528522
Year: 1984  Volume: 30  Issue: 5  Pages: 62-65
In order to elucidate whether specific estrogen-binding sites were heterogeneous, these sites were studied in uterine cytosols of guinea pig and green monkey Cercopithecus griseus. Concentrations of the estrogen-binding sites for labelled estrogens (estrone, estradiol, estriol and diethylstilbestrol) were estimated in the cytosols by means of the exchange method and Scatchard plot analysis. High linear correlation was shown between the Scatchard plots and the curves of estrogen-binding site complexes dissociation plotted in semilogarithmic coordinates (r-0.98 and 0.99, respectively; p less than 0.05). The linearity of the curves was confirmed by means of F-criterion. The data obtained suggest that only one type of specific estrogen-binding sites occurs in the cytosols at 30 degrees and at concentration of estrogens which did not exceed 50 nM. These estrogen-binding sites exhibited the same limited binding capacity for all the estrogens studied.
Download PDF:
Citation:

Alekseeva, M. L., Minina, L. S., Novikov, E. A., Shchedrina, R. N., Fanchenko, N. D. (1984). Possible heterogeneity of cytoplasmic estrogen receptors. Voprosy meditsinskoi khimii, 30(5), 62-65.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)