VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Immunological study of the identity of cytochrome P-448 in the mouse and rat liver after induction with 3-methylcholanthrene

   
Mishin V.M., Guliaeva L.F., Mishina D.V., Gutkina N.I.
PubMed Id: 6442038
Year: 1984  Volume: 30  Issue: 5  Pages: 98-102
As shown by means of Ouchterlony double immunodiffusion technique after induction with 3-methyl cholanthrene the antibodies towards cytochrome P-448 from rat liver tissue developed a clear-cut precipitation line with homologous antigen and interacted also with cytochrome P-448 from mice liver tissue although the precipitation was less distinct. Antibodies towards mice liver cytochrome P-448 reacted also with the rat liver cytochrome P-448 but less distinctly as compared with the mice cytochrome. At the same time, these antibodies inhibited similarly the benz(a)-pyrene-hydroxylase reaction, catalyzed by both mice and rat cytochromes P-448. Partial immunological identity appears to occur in the cytochromes studied. Role of total antigenic determinants in enzymatic reactions catalyzed by cytochrome P-448 is discussed.
Download PDF:
Reference:

Mishin V.M., Guliaeva L.F., Mishina D.V., Gutkina N.I. (1984) Voprosy meditsinskoi khimii, 30(5), 98-102.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
        

© Institute of Biomedical Chemistry, Moscow, Russia